[18F]FDG-PET/CT Heterogeneity in Patients with Metastatic, Well-Differentiated Pancreatic Neuroendocrine Tumours

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Introduction: 18F-FDG-PET/CT (FP) often shows an heterogeneous pattern of positivity in patients (P) with pancreatic neuroendocrine tumours (PanNETs).

Aim(s): To evaluate the incidence of FP positivity (FP+) and FP heterogeneity (H) in P with advanced, well differentiated (WD) PanNETs, and to analyze possible correlations with tumour grade (G).

Materials and methods: Baseline FP of P treated for metastatic, G 1-2 or WD G3 (Ki67 < 55%) PanNETs were retrospectively reviewed. FP was defined positive if at least one lesion had SUV max > 3.5. In a same FP+ P, categorical H (CaH: coexistence of FP positive and negative lesions) and continuous H (CoH: mean FP SUVmax difference between lesions) were calculated. FP+ and CaH rates were compared between G groups using Chi-square test. P values <0.05 were considered significant.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Ortolani S

Authors: Ortolani S, Cingarlini S, Citton E, Crosara S, De Robertis R,

Keywords: 18F-FDG-PET/CT, heterogeneity, pancreatic NETs,