Introduction: Insulinomas are usually small, single tumors. Precise preoperative localization of the tumor is essential. Imaging techniques like CT and MRI have limited sensitivity and also somatostatin receptor (SSTR) imaging is not specific. Exendin specifically binds the GLP-1 receptor (GLP-1R), which is markedly upregulated in insulinomas. 68Ga-DOTA-exendin-4 PET/CT has been shown to be feasible in detecting insulinomas. Replacing DOTA by NODAGA ensures higher specific activities. We propose 68Ga-NODAGA-exendin-4 PET/CT as a promising new method for improved localization of insulinomas.
Aim(s): We present the first cases of a multicenter prospective imaging study to evaluate the effectiveness of 68Ga-NODAGA-exendin-4 PET/CT.
Materials and methods: 4 adults aged 24-65 with hyperinsulinemic hypoglycemia were included. Standard imaging was performed in all patients, consisting of CT or MRI and SSTR PET imaging.
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Imaging (radiology, nuclear medicine, endoscopy)
Presenting Author: Msc. Marti Boss
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