Introduction: In PanNET tumors contradictory data about the prognostic role of MGMT (O6-methylguanine DNA methyltransferase) has been published. NDRG-1 (N-myc downstream-regulated gen-1) and PHLDA-3 (Pleckstrin homology-like domain family A member 3) immunohistochemistry (IHC) expressions have been evaluated in several solid malignant tumors, but their roles in PanNET remain unknown
Aim(s): We aimed to evaluate the prognostic significance of NDRG-1, MGMT and PHLDA-3 by IHC and methylation analysis in resected pancreatic neuroendocrine tumors.
Materials and methods: Ninety-two patients with resected primary PanNET and follow-up > 24 months were included in this study. An immunohistochemistry prognostic score (IPS) was developed based on MGMT, NDRG-1 and PHLDA-3 IHC expression to predict disease free survival (DFS) and overall survival (OS). The discriminatory ability of multivariate models combining the IPS and important clinical variables was assessed with Harrel’s c-index (HCI).
Conference: 13th Annual ENETS conference 2016 (2016)
Category: Basic Science - mTOR and other pathways, signalling, receptors
Presenting Author: Antonio Viudez
, Carvalho F
, Maleki Z
, Zahurak M
, Laheru D
, Stark A
, Azad N
, Wolfgang C
, Baylin S
, Herman J G
, De Jesus-Acosta A
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