A New Possibility in SI-NET Surgery by Using a New β- Probe and 90Y-DOTATOC: A Pilot Study

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Introduction: In neuroendocrine tumor (NET), complete surgery could better the prognosis of this disease: radioguided surgery (RGS) with beta-radioisotopes, as 90Y, is a novel approach focused on developing a new probe which, detecting electrons and operating with low background, provides a clearer delineation of the margins of lesions with low radiation exposition for surgeons.

Aim(s): To validate this RGS procedure, tests on ex vivo specimens of tumors expressing somatostatin receptors as small-intestine neuroendocrine (SI-NET) were performed.

Materials and methods: We studied these tumors due to the high uptake of 90Y-DOTATOC, a beta- emitting radiotracer. Patients were enrolled according to the tumor Standard Uptake Value (SUV) and the expected Tumor to Non-tumor Ratio (TNR) estimated from 68Ga-DOTATOC PET/CT images. Five SI-NET patients were submitted to PET/CT and entero-CT scan, 2 weeks prior to surgery. Twenty-four hours before surgery, patients received 5 mCi of 90Y-DOTATOC.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Grana C

Authors: Grana C, Bertani E, Collamati F, Faccini R, Pisa E,

Keywords: Small intestine neuroendocrine tumors, liver metastases, β- probe, 90Y-DOTATOC,