A Novel In Vitro Model of a Highly Proliferative Pancreatic Neuroendocrine Neoplasia

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Introduction: Transformation of well-differentiated neuroendocrine tumors into highly proliferative neuroendocrine neoplasms is a rare, but clinical relevant phenomenon. So far, it is unclear whether these tumors should be treated in analogy to neuroendocrine tumors or as bona fide neuroendocrine carcinoma.

Aim(s): To develope a new in vitro model to study treatment responses in tumor cells.

Materials and methods: We here report the establishment of a pair of neuroendocrine cell lines from the primary site and and from a liver metastasis of a patient with a neuroendocrine neoplasm. The patient was initially diagnosed with a G2 pancreatic neuroendocrine tumor. After several lines of treatment the tumor eventually transformed into a G3 (Ki-67 60%) neuroendocrine neoplasm.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Schrader J

Authors: Behrang Y, Benten D, Erbes J, Eggers C, Fahl M,

Keywords: cell line,