Introduction: Transformation of well-differentiated neuroendocrine tumors into highly proliferative neuroendocrine neoplasms is a rare, but clinical relevant phenomenon. So far, it is unclear whether these tumors should be treated in analogy to neuroendocrine tumors or as bona fide neuroendocrine carcinoma.
Aim(s): To develope a new in vitro model to study treatment responses in tumor cells.
Materials and methods: We here report the establishment of a pair of neuroendocrine cell lines from the primary site and and from a liver metastasis of a patient with a neuroendocrine neoplasm. The patient was initially diagnosed with a G2 pancreatic neuroendocrine tumor. After several lines of treatment the tumor eventually transformed into a G3 (Ki-67 60%) neuroendocrine neoplasm.
Conference: 13th Annual ENETS conference 2016 (2016)
Category: Basic Science - In vitro models, tumor growth, CTCs
Presenting Author: Dr Joerg Schrader
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