A Novel PKCßII Inhibitor Induces Antiproliferative Effects in Human Pancreatic Neuroendocrine Tumor Cells Abstract #265

Introduction: Deregulation of the protein kinase C (PKC) signaling pathway has been implicated in tumor progression.
Aim(s): To investigate the antiproliferative and antisecretory effects of a novel PKC inhibitor (PI) in the human pancreatic endocrine cancer cell line, BON1.
Materials and methods: Cell viability was investigated by ATPlite kit, apoptosis by caspase 3/7 assay, GSK3-ß phosphorylation and Chromogranin A (CgA) secretion by ELISA, PKCßII localization by immunofluorescence, CgA expression by Western blot.
Conference: 8th Annual ENETS Conference (2011)
Category: Basic
Presenting Author: MD Maria Chiara Zatelli

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