A Pilot Study on the Immunohistochemical Expression of Chromogranin and/or Synaptophysin in Moderate to Poorly Differentiated Gastroenteropancreatic Carcinomas Abstract #384

Introduction: Recent advances in specific treatment for neuroendocrine tumors (NETs) prompted us to reinvestigate the old phenomenon of neuroendocrine differentiation in carcinomas of the GI tract which has previously been shown to carry no prognostic significance.
Aim(s): We studied the immunohisotchemical expressions of chromogranin and synaptophysin in a group of ordinary adenocarcinomas of the gastrointestinal tract including the pancreas.
Materials and methods: A total of 100 cases of moderate to poorly differentiated adenocarcinomas of the stomach (eight), colon and rectum (83), pancreas (eight) and duodenum (one) were identified and tumor tissues were retrieved for immunohistochemical staining for chromogranin and synaptophysin.
Conference: 9th Annual ENETS Conference (2012)
Category: Clinical
Presenting Author: Dr tony W Shek
Keywords: NET, IHC

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