Introduction: Pasireotide is a somatostatin analog (SSA) that targets somatostatin receptor subtypes 1-3 and 5. An earlier phase I study showed antitumor activity of everolimus+pasireotide LAR (EVE+PAS) in NET.
Aim(s): To assess the efficacy and safety of EVE+PAS compared to EVE alone in patients (pts) with advanced, progressive pNET.
Materials and methods: We performed a randomized, open-label, phase II study of EVE±PAS in pts with advanced G1/G2 pNET; stratified by prior SSA use, baseline CgA and/or NSE. Primary endpoint was PFS. Secondary endpoints included RECIST-defined tumor response rate, overall survival (OS), and safety.
Conference: 12th Annual ENETS Conference 2015 (2015)
Category: Medical treatment - Targeted therapies
Presenting Author: Dr. Matthew H Kulke
Kulke M H
, Ruszniewski P
, Van Cutsem E
, Valle J
, De Herder W
, Pavel M
, Degtyarev E
, Lam D
, Salazar R
, Borbath I
, Fazio N
, Lombard-Bohas C
, Yao J C
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Introduction: Pasireotide (SOM230) is a novel multi-receptor ligand somatostatin analogue with high affinity for somatostatin receptor subtypes sst1,2,3 and sst5. Like octreotide, which binds primarily to sst2, it inhibits hypersecretion of hormones from patients with functional pituitary tumors and gastroenteropancreatic neuroendocrine (GEP/NET) tumors. In addition, tumor shrinkage has been observed with both compounds in patients with acromegaly, Cushing’s disease and GEP/NETs, but its tumor-reducing mechanism of action has so far not been revealed. In patients with breast and liver cancer, octreotide had little or no antitumor activity.
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