A Retrospective Multicentre Evaluation of the Outcomes and Management of Carcinoid Heart Disease in Patients with Advanced Midgut NETs: A NET-CONNECT Descriptive Study

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Introduction: Carcinoid heart disease (CHD) is a poor prognostic factor in neuroendocrine tumours (NETs). However, the extreme variability of diagnostic and treatment approaches reported in literature account for uncertainties on the best management in this selected population.

Aim(s): To evaluate the clinical management of patients with advanced midgut NET diagnosed with CHD and correlate clinico-pathological parameters to overall survival (OS).

Materials and methods: A multicentre retrospective cohort study in patients with midgut NET diagnosed with CHD by echocardiography (EC) (2008-2018). OS was calculated from the time of CHD diagnosis to the date of death or last follow-up. Survival curves were estimated using the Kaplan-Meier method. Univariate and multivariable hazard ratios were estimated using Cox regression models.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Spada F

Authors: Spada F, Laskaratos F, Crona J, Oleinikov K, Zandee W,

Keywords: Carcinoid Heart Disease, NETs, Carcinoid Syndrome, Midgut NETs,