Introduction: Vitamin D deficiency is hypothesized to represent a risk factor in several neoplasms.
Aim(s): The aim of this study was to determine whether serum 25-hydroxyvitamin D (25-OHvitD) deficiency represents a risk factor for neuroendocrine neoplasms (NENs) and can be associated to overall survival (OS) and progression-free survival (PFS).
Materials and methods: From 2010 to 2015 138 patients with gastro-entero-pancreatic NENs (F=61, median age 63 years) were included in the study. Serum 25-OHvitD levels, measured at baseline, were defined as deficient if <20 ng/ml. In such cases 25-OHvitD supplementation was administered to the patients. The possible associations between 25-OHvitD levels and disease grading, staging, overall OS and PFS were considered. Furthermore, the possible association between 25-OHvitD supplementation and PFS or OS was evaluated by Cox’s proportional hazards regression.
Conference: 14th Annual ENETS conference 2017 (2017)
Category: Epidemiology/Natural history/Prognosis - Prognosis
Presenting Author: Alessandra Zilli
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