A Single Fasting Plasma 5-HIAA Value Correlates with 24-Hour Urinary 5-HIAA Values and Other Biomarkers in Midgut Neuroendocrine Tumors (NETs)

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Introduction: 5-hydoxyindoleacetic acid (5-HIAA) is used for the evaluation of neuroendocrine tumors (NETs), however, the current 5-HIAA assay requires a 24-hour urine collection which is inconvenient.

Aim(s): We developed a gas chromatography-mass spectroscopy (GC-MS) based plasma 5-HIAA assay.

Materials and methods: We compared 24-hour urine 5-HIAA values with single fasting plasma 5-HIAA values in 115 mixed variety NET patients, a subset of 72 patients with only small bowel NETs, and another subset of 47 patients with small bowel NETs with liver metastasis. We also compared the information gained from urinary and plasma 5-HIAA values with other biomarkers of midgut NET activity in order to determine the plasma assay’s clinical implications.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Tellez M, Mamikunian G, Go V, O'Dorisio T, Vinik A,

Keywords: 5 Hydroxyindoleacetic acid, 5-HIAA, neuroendocrine tumors, midgut, serotonin, carcinoid syndrome,