A Small Mixed Adenocarcinoma and Neuroendocrine Tumor of the Duodenum with Multiple Liver Metastases

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Introduction: Mixed adenocarcinoma and neuroendocrine cancers (MANECs) are rare specific type of tumors that are composed of two histologic components: a neuroendocrine carcinoma and an adenocarcinoma. There are only a few reports regarding MANEC of the stomach, colon and rectum in the literature.

Aim(s): We present a unique case of a small duodenal MANEC with multiple liver metastases at presentation.

Materials and methods: A 59 y/o female presented with abdominal pain, nausea, and vomiting and weight loss. Abdominal sonograpgy showed lymphadenopathies in celiac plexus and porta hepatis area and multiple hypoechoic nodules in liver. Abdominal CT scan without contrast showed multiple hyper dense lesions in liver and lymphadenopathies in porta hepatis area. Upper GI endoscopy revealed a 5 mm small nodular lesion in duodenum. Biopsies of both duodenal and liver lesions were performed and pathologic findings and IHC study on both of them showed a mixed adenocarcinoma/neuroendocrine tumor.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Eishi Oskuie A, Valizadeh N, Shateri K,

Keywords: MANECs, adenocarcinoma, neuroendocrine tumor, mixed, metastases,