A Three Tier Grading System Based on Ki-67 Index, Mitotic Count and Necrosis with Cut-Offs Specifically Generated for Lung Neuroendocrine Tumors is Prognostically Effective and Accurate

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Introduction: Lung neuroendocrine tumors are catalogued into four categories by the World Health Organization (WHO 2004) classification. Its reproducibility and prognostic efficacy was disputed. The WHO 2010 classification of digestive neuroendocrine neoplasms is based on a Ki-67 index and has proved prognostically effective.

Aim(s): To compare the two classifications and to define a new prognostic grading system for lung.

Materials and methods: Three-hundred and ninety-nine patients who underwent surgery and with at least one year follow-up between 1989-2011. Twenty-one variables were collected and performance of grading systems and their components compared by Cox regression and multivariable analyses; all tests were two-sided.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Rindi G, Klersy C, Inzani F,

Keywords: lung, neuroendocrine cancer, Ki-67, grading,