Abstract Library

#142 The role of 18F DOPA-PET in a case of malignant pheochromcytoma

Introduction: Pheocromocytoma is a rare tumor arising from chromaffin cells of adrenal medullary or extra adrenal paraganglionic tissue. Histological criteria cannot differentiate benign from malignant pheocromocytomas. The diagnosis of a malignant pheocromocytoma requires local invasion, recurrence and documented metastatic disease. The radionuclide scanning (123I - 131I-MIBG) is a fundamental diagnostic tool used to confirm the biochemical and radiological diagnosis of pheochromocytoma. In fact, MIBG scanning may confirm that the visualised lesion in an adrenal gland is indeed a pheochromocytoma and detect extra-adrenal paraganglionic tissue. However, MIBG scans are negative in around 15% of benign pheochromocytomas and in up to 50% of malignant ones. Other radionuclide techniques (18FDG-PET, 18F-DOPA-PET, 18F-FDA-PET) have been successfully used in investigation of pheochromocytomas. 18F-DOPA-PET and 18F-FDA-PET have been reported to be highly sensitive and specific for benign pheochromocytomas, while 18FDG-PET can be useful for malignant lesions with higher metabolic activity.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: De Marinis L

Authors: Lugli F, Fusco A, Bianchi A, Iacovazzo D, Mormando M,

Keywords: malignant pheochromocytoma, 18F-DOPA-PET, MIBG,

#135 The importance of endoscopic ultrasound in detecting recurrent gastrinoma in a case of MEN 1

Introduction: Approximately 25-30% of patients have gastrinomas as part of the inherited syndrome Multiple Endocrine Neoplasia 1 (MEN 1). Gastrinomas occur in the pancreas, duodenum or peripancreatic lymph nodes. Diagnosis is made by clinical history, gastroscopy, and measurement of serum gastrin, gastric juice pH, CT scan, endoscopic ultrasound (EUS) and somatostatin receptor scintigraphy (SRS). Localization of gastrinomas in patients with MEN 1 is challenging due to their small size, frequent duodenal location, and multiplicity.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: De Marinis L

Authors: Fusco A, Lugli F, Bianchi A, Iacovazzo D, Larghi A,

Keywords: endoscopic ultrasound, gastrinoma, MEN 1 ,