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#2965 Molecular Signature of Rectal Neuroendocrine Neoplasia
Introduction: Rectal neuroendocrine tumors are rare neuroendocrine neoplasias (NEN). Little is known about prevalence and type of somatostatin receptor subtypes (sstr) expression and somatic mutations in relation to long-term clinical outcome.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Unger N, Theurer S, Herold T, Weber F, Dralle H,
Keywords: Somatic Mutations, NGS, Somatostatin receptor subtypes, Intestinal NEN,
Introduction: Immuno check-point inhibitors development in grade 1-2 NENs is limited by low mutation tumor load and PD-1/PDL-1 expression. The combination of an PDL-1 and CTLA-4 inhibitors could increase the probability of success in this setting. In high grade NENs the rational for immunotherapy is stronger based on experiences in small cell lung cancer.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Hernando-Cubero J
Authors: Hernando-Cubero J, Manzano J, Benavent M, Lopez C, Teulé R,
Keywords: Durvalumab, Tremelimumab, Neuroendocrine, Immunotherapy,
Introduction: Prognostic impact of well differentiated pancreatic neuroendocrine neoplasms (PanNENs) with a Ki67 >20%, provisionally called NET G3, needs to be validated and compared to poorly differentiated neuroendocrine carcinomas (NECs). Moreover, the frequency of NET G3 among gastrointestinal NENs (GI-NENs) has so far not been studied.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Kasajima A
Authors: Kasajima A, Tachibana T, Ishida H, Yazdani S, Konukiewitz B,
Introduction: Small intestinal NEN (SI-NEN) is much rarer in Asian countries. Hence, the clinicopathological characteristics of SI-NEN are still unknown in Asian population.
Conference: 14th Annual ENETSConcerence (2017)
Presenting Author: Chen L
Authors: Chen L, Zhou L, Zhang M, Shang L, Wang W,
Keywords: small intestine, neuroendocrine neoplasms, clinicopathological features,
Introduction: Small intestine neuroendocrine neoplasm (SINENs) are heterogeneous neoplasms arising from endocrine cells of the intestinal mucosa. Ki67 is the main determinant of prognosis in NENs. However, the research for new prognostic makers represent a key-point. The oncofetal protein IMP3 plays a role in cell growth and its expression has a prognostic value in lung neoplasms.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Cavalcoli F
Authors: Massironi S, Del Gobbo A, Cavalcoli F, Fiori S, Conte D,
Keywords: IMP3, intestinal NENs,