Abstract Library

#2743 Mimics of Neuroendocrine Neoplasms Identified in a Single Consultation Center between 2009 and 2019

Introduction: Immunohistochemical expression of synaptophysin (SYN), chromogranin (CgA) and cytokeratin are essential for diagnosis of NENs. Non-NENs, however, may occasionally also express NE-markers and cytokeratin and cause diagnostic difficulties.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Kasajim A

Authors: Kasajima A, Konukiewitz B, Schlitter A, Weichert W, Klöppel G,

Keywords: pitfalls, pathology diagnosis,

#2279 Expression of FOXM1 in G3 Neuroendocrine Tumors (NET G3) and G3 Neuroendocrine Carcinomas (NEC G3) of the Pancreas and the Intestine

Introduction: G3 gastroenteropancreatic neuroendocrine tumors (G3 NET) and carcinomas (G3 NEC) differ considerably concerning their biological behavior and patients outcome. Whereas the WHO2017 classification for pancreatic NETs proposes a distinction of both groups using the Ki-67 proliferation marker (Klöppel et al. Reviews and Reports 2017), a useful marker for the subclassification of G3 intestinal NETs have not been recommended until now.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Briest F

Authors: Briest F, Konukiewitz B, Anlauf M, Klöppel G, Grabowski P,

Keywords: gastroenteropancreatic neuroendocrine tumors, GEP-NET, NET G3, NEC G3, Tumor marker, FOXM1, Ki-67, differentiation,

#565 Proliferative Activity is Not Associated with Tumor Aggressiveness in Ileal Neuroendocrine Tumors

Introduction: The accuracy of the new WHO grading system for neuroendocrine neoplasms has not yet been validated for ileal neuroendocrine tumors (iNETs).

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Sperveslage J, Anlauf M, Klöppel G, Neumayer B,

Keywords: ileal NET, proliferation, prognosis,

#564 Genetic Alterations in Glucagon Cell Adenomatosis

Introduction: Glucagon cell adenomatosis (GCA) was recently recognized by us as a multifocal neoplastic disease of the endocrine pancreas unrelated to MEN-1. Multiple micro- and a few macrotumors are found on the background of a hyperplasia of glucagon cells. The disease may cause unspecific abdominal symptoms and only rarely a glucagonoma syndrome. Recently a mutation in the glucagon receptor (GCGR) gene was described in one GCA patient.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Henopp T, Anlauf M, Biskup S, Klöppel G, Sipos B,

Keywords: glucagon,

#558 MANECs Among Colorectal Signet Ring Cell Carcinomas

Introduction: The mixed adenoneuroendocrine carcinomas (MANEC, WHO 2010) are neoplasms with heterogeneous morphology, whose mixed nature may be difficult to recognize.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Hermann G, Yarom N, Konukiewitz B, Sandbank J, Klöppel G,

Keywords: manec, signet ring cell carcinoma, colon, rectum,