Abstract Library
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Introduction: Grade 3 (G3) neuroendocrine neoplasms (NEN), arising from the gastro-entero-pancreatic system (GEP), are classified according to WHO 2010 and defined as having a Ki67 of > 20%. However this groups together G3 well differentiated neuroendocrine tumours (WD-NET) with poorly differentiated neuroendocrine carcinomas (PD-NEC). Recently, WHO have proposed a new classification for pancreatic NEN, with sub-division into G3 WD-NET and G3 PD-NEC
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Furnace M
Authors: Furnace M, Muller G, Rundell C, Shah R, Luong T,
Keywords: G3, well-differentiated, poorly differentiated, Ki-67,
Introduction: DIPNECH is considered a rare condition and the natural history is poorly described. It is thought to give rise to pulmonary carcinoids (PCs) (>5mm) or tumourlets (≤5mm).
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Hayes A
Authors: Hayes A, Banks J, Shah H, Luong T, Navalkissoor S,
Keywords: dipnech, diffuse idiopathic neuroendocrine cell hyperplasia, tumourlet, carcinoid, neuroendocrine tumor, multiple pulmonary nodules,
Introduction: Pulmonary carcinoids (PC) are well-differentiated NETs and are classified as typical carcinoid (TC) and atypical carcinoid (AC). Despite the fact that TC and AC exhibit significant differences in patient survival, their classification depends on relatively subtle differences in mitotic count (MC). Although careful counting of mitotic figures (MF) is essential, it is a very subjective task, time-consuming and lacks of sensitivity and interobserver reproducibility, due to selection bias of the hot spots, heterogeneous distribution of MF, difficulty in distinguishing MF from similar chromatin changes (i.e. in apoptotic cells or due to crush, karyorrhectic debris, pyknosis or apoptosis).
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Luong T
Authors: Luong T, McCaughran W, Caplin M, Toumpanakis C, Thirlwell C,
Keywords: Phosphohistone H3, Pulmonary Carcinoids, Typical Carcinoid, Atypical Carcinoid, Mitotic Count, H&E,
Introduction: Colorectal poorly differentiated neuroendocrine carcinomas (NECs) are rare, but extremely aggressive. The mechanisms of their carcinogenesis and aggressiveness are still largely unknown. Recently Nobuyoshi Takizawa showed that the molecular features of colorectal NECs are similar to those of adenocarcinoma and not to those of NETs and they were more evident in small cell NECs than in large cell NECs. This is supported by combined cases with conventional adenoma/adenocarcinoma and NECs. Stelow et al showed that DNA mismatch repair proteins were intact in 14/15 colorectal small cell NECs. Two cases of LCNECs arising from SSL have been reported so far in the literature.
Conference: 15th Annual ENETSConcerence (2018)
Presenting Author: Luong T
Keywords: Large cell neuroendocrine carcinoma, sessile serrated lesion, microsatellite instability, MMR protein, BRAF mutation,
#1415 Detection of SSTR2 and 5 Expression on Circulating Tumour Cells in Neuroendocrine Tumours
Introduction: Neuroendocrine tumours (NET) overexpress somatostatin receptors (SSTR) which can be targeted for therapy with somatostatin analogues (SSA) or radionuclide treatment.
Conference: 13th Annual ENETSConcerence (2016)
Presenting Author: Childs A