Abstract Library

#603 Role of Semaphorins and Their Signaling Pathway in the Progression of Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs)

Introduction: Semaphorin family, a part of axon guidance molecules, is involved in many types of epithelial cancers. However, little is known about its potential function in GEP-NETs.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Bollard J, Massoma P, Blanc M, Vercherat C, Lepinasse F,

Keywords: semaphorins, progression, biomarker,

#602 Antitumoral Effect of Everolimus in Preclinical Models of Poorly Differentiated Neuroendocrine Carcinomas

Introduction: For the small and large cells poorly differentiated neuroendocrine carcinomas (PDNECs) emergency treatment remains the combination cisplatin/etoposide. However, recent studies suggest that targeted therapies could be a therapeutic option for this group of highly aggressive carcinomas.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Bollard J, Couderc C, Blanc M, Poncet G, Lepinasse F,

Keywords: everolimus, poorly differentiated neuroendocrine carcinoma, preclinical study,

#204 A Proteomic Approach Identifies Novel Proteins Involved in Invasion Mechanisms in Enteroendocrine Carcinomas

Introduction: Enteroendocrine tumors dramatically lack reliable biomarkers to accurately select therapeutic strategy, due to a poor knowledge of molecular mechanisms leading to local invasion and dissemination.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Couderc C, Poncet G, Pourpe S, Couté Y, Lepinasse F,

Keywords: enteroendocrine carcinoma, invasion, biomarkers, proteomic,

#113 Prolonged cell survival in xenografts from human digestive endocrine tumors

Introduction: Gastroenteropancreatic endocrine tumors have the capacity to achieve very large tumor masses despite usually very low proliferative rates. This suggests that neoplastic endocrine cells may have long life spans, implying the development of specific mechanisms able to promote cell survival.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Poncet G

Authors: Poncet G, Lépinasse F, Hervieu V, Hommell J, Walter T,

Keywords: human grafted tumors, cell survival, morphological differentiation,