#3053
The Splicing Machinery Is Dysregulated in Low Grade Pulmonary Neuroendocrine Tumors
Introduction:
Alternative splicing dysregulation is increasingly regarded as a novel cancer hallmark influencing all key tumor features. We have shown that neuroendocrine tumors (NETs) overexpress aberrantly spliced variants of neuropeptides and receptors that increase tumor malignancy. More recently, we discovered that the splicing machinery is dysregulated in pituitary and pancreatic NETs. To date, the status of this machinery in low grade pulmonary NETs is largely unknown.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Blázquez-Encinas R
Authors:
Blázquez-Encinas R,
Caro M,
Pedraza-Arévalo S,
Alors-Pérez E,
Herrera-Martínez A,
Keywords:
low grade pulmonary NETs,
splicing,
splicing machinery,
malignancy,
#3032
Lung Side and Site: The Importance of Location and the Prognostic Implication in Lung Neuroendocrine Tumors
Introduction:
Lung neuroendocrine tumors (NET) are classified as typical (TC) and atypical carcinoids (AT), according to their mitotic count and the presence of necrosis. However, a role for tumor side (right vs left) and location (central vs peripheric) has not been established so far.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
La Salvia A
Authors:
La Salvia A,
Trevisi E,
Brizzi M,
Espinosa Olarte P,
Enguita A,
Keywords:
Lung neuroendocrine tumors,
tumor side (left versus right),
tumor site (peripheric versus central),
prognostic factors,
survival,
#3030
Targeting CXCR4 and Thioredoxin Reductase in Theranostics of Atypical Carcinoid and Neuroendocrine Carcinoma
Introduction:
Atypical carcinoid and small cell lung cancer (SCLC) are currently incurable. There is thus a critical need for new diagnostic and therapeutic strategies for lung neuroendocrine neoplasms (LNEN). Chemokine receptor 4 (CXCR4), a G protein coupled receptor and theranostic target, plays a crucial role in metastases of LNEN. We hypothesize combination of thioredoxin reductase (TR) inhibitor represents a metabolic strategy to enhance cytotoxicity in peptide-receptor radionuclide therapy (PRRT) of LNEN.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Liu D
Authors:
Liu D,
Fath M,
Robles Planells C,
Balk E,
Bellizzi A,
Keywords:
CXCR4,
thioredoxin reductase inhibitor,
theranostics,
atypical carcinoid,
small cell lung cancer,
#3015
Biopsy Specimen Diagnosis in Pulmonary Carcinoids, A Shot in the Dark
Introduction:
Pulmonary carcinoids (PCs) are rare well-differentiated neuroendocrine tumors, which can be separated into typical carcinoid (TC) and atypical carcinoid (AC). Advised treatment for local carcinoid disease is surgical resection using lobectomy, while parenchymal saving strategies such as sub-lobar or endobronchial resection might be considered for TC. In general, pre-operative diagnosis using a (transbronchial/transthoracic) biopsy sample is performed to demonstrate malignancy. However, TC and AC classification can solely be performed on surgical resection specimens, which may challenge pre-operative treatment decisions.
Conference:
17th Annual ENETSConcerence (2020)
Presenting Author:
Moonen L
Authors:
Moonen L,
Derks J,
Hermans B,
Dingemans A,
Speel E,
Keywords:
pulmonary,
neuroendocrine,
carcinoid,
biopsy,
resection,
diagnosis,
