Abstract Library

#2963 Intrinsic Gene Programs in Metastasis-like Primary Subtype Is Associated with Early Metastatic Evolution in Pancreatic Neuroendocrine Tumours

Introduction: Three molecular subtypes of pancreatic neuroendocrine tumours (PanNETs) have been described: insulinoma-like, intermediate and metastasis-like primary (MLP). The Latter is a non-functional tumours with highly metastatic potential. A mouse model of PanNET showed that MLP subtype has two different pathways of progression including stem/progenitor and epithelial-to-mesenchymal transition. However, the evolution of metastasis in patients requires further studies.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Sadanandam A

Authors: Sadanandam A, Lawlor R, Nyamundanda G, Ragulan C, Scarpa A,

Keywords: Pancreatic neuroendocrine tumors, metastasis, metastatic evolution, early metastasis, recurrence, prognosis, Patient tumours, cause and effect relationship, computational modeling, molecular subtypes, stages, metastatic potential,

#1803 Type 3 Gastric Neuroendocrine Neoplasms: Relationship Between Tumor Size, Ki67 and Clinical Outcome

Introduction: Sporadic type 3 gNENs are usually malignant with high metastatic potential, mostly large, with a high grade histology. However, little is known on the relationship between tumor size, proliferative index Ki67, and clinical outcome

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Panzuto F

Authors: Panzuto F, Campana D, Faggiano A, Massironi S, Rinzivillo M,

Keywords: gastric neuroendocrine tumors, ki67, tumor size,

#688 Does Small Mean Benign? Not for the WHO 2010 Classification of Gastrointestinal Neuroendocrine Tumors (NETs): A Case Report of a Small Rectal Neuroendocrine Neoplasm (NEN) with Distant Metastatic Spread

Introduction: The gastrointestinal tract is the most common site of primary NETs, just over a quarter of which are rectal. According to the WHO 2000/2004 non-functioning NETs, ≤2cm with no muscularis propria or vascular invasion are classified as well differentiated (WD) NET with benign behavior. However, several case series report metastatic spread from NETs in this category. In 2010, a new WHO classification was introduced with the premise that all NETs were considered malignant with metastatic potential.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Green A, Cheung V, Toumpanakis C, Caplin M, Luong T,

Keywords: neuroendocrine tumor, WHO,

#466 HIF-1a Determines the Metastatic Potential of the GEP-NET Cell Line BON-1

Introduction: Intratumoral hypoxia is a hallmark of solid tumor formation and a negative predictor of patient survival. Adaptation to hypoxia is mainly achieved by the transcription factor HIF-1a, which is upregulated in a diverse range of human and experimental tumors and their metastases. HIF-1a target genes have been implicated in the induction of invasion and metastasis. However, HIF-1a’s tumor-supporting action depends on cell type and microenvironment and the precise role of HIF-1a for the pathogenesis of neuroendocrine tumors (NET) is largely unknown.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Freitag de Molina K, Rohwer N, Detjen K, Wiedenmann B, Cramer T,

Keywords: hypoxia, hif-1a, metastases,

#295 Unusual Behavior of Gastric Carcinoid Type 1

Introduction: Gastric carcinoids (GC) are rare tumors of the stomach. GC type 1 are associated with chronic atrophic gastritis (CAG) and are the most benign type, having low metastatic potential.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Spampatti M, Massironi S, Rossi R, Conte D, Ciafardini C,

Keywords: gastric carcinoid type 1, metastatic disease, well-differentiated endocrine tumors, Ki-67index,