Abstract Library

#1446 Morphological Differentiation and Ki67-Index Are Predictive of Prognosis Independently of the Type of Therapy in Gastroenteropancreatic Neuroendocrine Carcinomas (NECs)

Introduction: Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are considered an heterogeneous category.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Milione M

Authors: Milione M, Maisonneuve P, Spada F, Pellegrinelli A, Spaggiari P,

Keywords: Ki-67, OS, PFS, NEC,

#1286 A Comparative Analysis of Ki67 Index of the High Grade Neuroendocrine Neoplasms Arising in the Gastrointestinal Tract and the Pancreas

Introduction: A common classification has been used for NET in gastrointestinal tract (GI-NET) and pancreas (P-NET), but heterogeneity has been reported in high grade tumors; well-differentiated G3 (WDG3), poorly differentiated NEC (NEC), and mixed adenoneuroendocrine carcinoma (MANEC).

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Kasajima A, Ishida H, Tachibana T, Yazdani S, Sasano H,

Keywords: high grade tumors, morphological differentiation, ki-67 index,

#920 High Grade (G3) Neuroendocrine Neoplasms Should Be Further Classified According to Morphological Differentiation

Introduction: Neuroendocrine neoplasms (NENs) with a Ki-67 >20% (Grade 3) are classified together as Neuroendocrine Carcinomas (NEC), and are usually considered as poorly differentiated. However Grade (G)3 NENs may be heterogeneous, with some demonstrating a well-differentiated cell morphology.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Mandair D, O'Leary J, Luong T, Thirlwell C, Meyer T,

Keywords: Ki-67, g3 NENs,

#113 Prolonged cell survival in xenografts from human digestive endocrine tumors

Introduction: Gastroenteropancreatic endocrine tumors have the capacity to achieve very large tumor masses despite usually very low proliferative rates. This suggests that neoplastic endocrine cells may have long life spans, implying the development of specific mechanisms able to promote cell survival.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Poncet G

Authors: Poncet G, Lépinasse F, Hervieu V, Hommell J, Walter T,

Keywords: human grafted tumors, cell survival, morphological differentiation,