Abstract Library

#2958 The Blood-based Multigenomic NETest Accurately Identifies Neuroendocrine Transformed Prostate Cancer

Introduction: Neuroendocrine differentiation and an aggressive phenotype is an important feature of castration-resistant prostate cancer (CRPC). Current biomarkers are unable to detect these advanced, treatment refractory variants.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Modlin I

Authors: Modlin I, Kidd M, Rahbar K, Malczewska A, Rajwa P,

Keywords: Biomarker, NETest, PSA, prostate cancer, neuroendocrine phenotype, castration-resistance, neuroendocrine,

#2196 The Neuroendocrine Phenotype, Genomic Profile, and Therapeutic Sensitivity of GEPNET Cell Lines

Introduction: Patient tumour-derived cell lines have been widely used for studying the molecular mechanisms of tumours and their response to therapy. The establishment of cell lines from gastro-entero-pancreatic neuroendocrine tumours (GEPNETs) has proved difficult, but despite the challenges a limited amount of cell lines now exists.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author:

Authors: Hofving T, Arvidsson Y, Almobarak B, Inge L, Pfragner R,

Keywords: neuroendocrine tumor, GEP-NET, immunophenotyping, copy-number alterations, exome sequencing, inhibitor screening, vorinostat, trametinib,

#2148 Tumor Microenvironment in Merkel Cell Carcinoma: Association with Merkel Cell Polyomavirus and Clinico-Pathological Features in a Retrospective Cohort Study

Introduction: MCC is a rare and aggressive skin cancer with a neuroendocrine phenotype.Association between MCC and Polyomavirus is known.PD-1 and PD-L1 have recently become key players in the therapeutic landscape.

Conference: 15th Annual ENETSConcerence (2018)

Presenting Author: Birocco N

Authors: Mecca C, Maletta F, Caliendo V, Birocco N, Metovic J,

Keywords: merkel cell carcinoma, microenvironment, polyomavirus,

#1183 Establishment of a New Human Pancreatic Neuroendocrine Tumour Cell Line

Introduction: The development of new therapeutic strategies for patients with pancreatic neuroendocrine tumours is impaired by the paucity of suitable pre-clinical models. Although the two available tumour cell lines BON and QGP have a neuroendocrine phenotype, the proliferation rate is too high for a well differentiated neuroendocrine tumour.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Schrader J

Authors: Schrader J, Benten D, Rhotert C, Fahl M, Perez D,

Keywords: neuroendocrine, cell line, pancreas,

#340 Aggressive Somatostatinoma, with Associated Pheocromocytoma in a Neurofibromatosis Patient

Introduction: Neurofibromatosis is associated with a neuroendocrine phenotype as pheocromocytoma, primary hyperparathyroidism and gastropancreatic neuroendocrine tumors.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Poiana C, Carsote M, Radoi V, Ene C, Gruia A,

Keywords: somatostatinoma, neurofibromatosis, pheocromocitoma, octreotidum,