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#3028 Pancreatic Neuroendocrine Neoplasms: Dissecting the Molecular Heterogeneity
Introduction: Pancreatic neuroendocrine neoplasms (PNENs) are a group of rare but biologically and clinically heterogeneous neoplasms with variable patient outcomes. Little is known about the molecular differences between PNENs and the biologic significance of such divergence.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Yang K, Kalloger S, Aird J, Lee M, Colborne S,
Keywords: Pancreatic neuroendocrine neoplasms, Exome, Transcriptome, Proteome,
Introduction: As per recommendations, a Peptide Receptor Radionuclide Therapy (PRRT) with Lu-177 DOTATATE course usually consists of 4 cycles. Patients may discontinue a PRRT course early, either due to progression or toxicity. Limited data are available about predictive factors for PRRT early discontinuation.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Julian G
Authors: Gertner J, Groves J, Aziz B, Miah L, Furtado O'Mahony L,
Keywords: prrt,
Introduction: Pancreatic neuroendocrine neoplasms (pNENs) and gastrointestinal stromal tumours (GISTs) are both rare neoplasms, and they have an estimated incidence of about 1/100,000 per year and about 1-1.5/100,000 per year, respectively.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Milanetto A, Pacciani S, Da Broi M, Gais Zürcher A, Fassan M,
Keywords: pancreatic neuroendocrine neoplasm, gastrointestinal stromal tumour, pancreatic surgery,
Introduction: Serotonin-secreting pancreatic neuroendocrine neoplasms (5-HT-secreting pNENs) are very rare. They are characterised by high urinary 5-hydroxyindole-acetic acid (5-HIAA) levels (or high serum 5-HT levels).
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Milanetto A, Fassan M, Gais Zürcher A, David A, Pasquali C,
Keywords: Pancreatic neuroendocrine neoplasm, primary pancreatic carcinoid, serotonin-secreting pancreatic tumour, serotonin-producing pancreatic tumour,
Introduction: Prognosis of pNENs depends on staging and grading, based on the cyto-histological Ki67 labelling; EUS-FNA is considered the gold standard technique to obtain it in pre-therapeutic setting
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Tacelli M
Authors: Tacelli M, Petrone M, Capurso G, Rossi G, Archibugi L,
Keywords: Pancreatic neuroendocrine neoplasms, Grading, EUS-FNA, Endoscopic ultrasound-Fine Needle Aspiration, Ki-67, WHO, misclassification,