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#2965 Molecular Signature of Rectal Neuroendocrine Neoplasia
Introduction: Rectal neuroendocrine tumors are rare neuroendocrine neoplasias (NEN). Little is known about prevalence and type of somatostatin receptor subtypes (sstr) expression and somatic mutations in relation to long-term clinical outcome.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author:
Authors: Unger N, Theurer S, Herold T, Weber F, Dralle H,
Keywords: Somatic Mutations, NGS, Somatostatin receptor subtypes, Intestinal NEN,
Introduction: Pasireotide is a somatostatin analog (SSA) that targets somatostatin receptor subtypes 1-3 and 5. An earlier phase I study showed antitumor activity of everolimus+pasireotide LAR (EVE+PAS) in NET.
Conference: 12th Annual ENETSConcerence (2015)
Presenting Author:
Authors: Kulke M, Ruszniewski P, Van Cutsem E, Valle J, De Herder W,
Keywords: everolimus, pNET, pasireotide LAR,
Introduction: Diagnostics and therapy of NET are significantly influenced by their somatostatin receptor (SSTR) status. Immunohistochemistry (IHC) of SSTR performed by pathologists is a time-consuming and cost-intensive procedure.
Conference: 11th Annual ENETSConcerence (2014)
Presenting Author:
Authors: Kaemmerer D, Athelogou M, Lupp A, Schulz S, Peter L,
Keywords: SSTR,
Introduction: Expression of somatostatin receptor subtypes (sstr) is required for the successful use of somatostatin analogues (SSA) in the treatment of neuroendocrine tumors (NET). Reliable detection of sstr could improve the selection of SSA treatment. Rabbit and mouse monoclonal antibodies (mAbs) were recently developed independently in Jena and Basel.
Conference: 9th Annual ENETSConcerence (2012)
Presenting Author:
Authors: Lambertini C, Nuciforo P, Schulz S, Schmid H,
Keywords: sstr, NET, sstr-specific mAb,
Introduction: A lack of well-characterized somatostatin receptor (sstr)-specific antibodies has hampered development of routine sstr expression profiles that may be useful in the treatment of NET patients (pts).
Conference: 8th Annual ENETSConcerence (2011)
Presenting Author:
Authors: Lambertini C, Schmid H, Kaufmann M, Nuciforo P,
Keywords: Somatostatin receptor, neuroendocrine tumors, somatostatin receptor-specific monoclonal antibodies,