Abstract Library

#981 Parathyroid Hormone-Related Peptide (PTHrP) Secretion by Metastatic Gastroenteropancreatic Neuroendocrine Tumors (GEP-NET): Clinical Features, Diagnosis, Management, and Long-Term Follow-Up

Introduction: There are a few large series of patients with parathyroid hormone (PTH)-related protein (PTHrP) secreting neuroendocrine tumors (NETs) causing severe hypercalcemia.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author:

Authors: Kamp K, Feelders R, De Rijke Y, Van Nederveen F, Kwekkeboom D,

Keywords: PTH, PTHrP, net, hypercalcemia,

#246 SDHB Loss Predicts Malignancy in Pheochromocytomas/Sympathethic Paragangliomas, but Not Through Hypoxia Signalling

Introduction: To date there is no reliable histopathological marker of malignancy for pheochromocytomas/sympathetic paragangliomas (PCC/PGL). It is well-known that PCC/PGL in the hereditary context of an SDHB germline mutation very often metastasize. The immunohistochemical loss of SDHB expression was recently shown to be a surrogate marker for the presence of an SDH germline mutation in PCC/PGL. SDHB loss is supposed to be tumorigenic via activation of hypoxia signals.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Schmitt A, Blank A, Korpershoek E, van Nederveen F, Rudolph T,

Keywords: SDHB loss, immunohistochemistry, pheochromocytoma, paraganglioma, malignancy, hypoxia,