A Proteomic Approach Identifies Novel Proteins Involved in Invasion Mechanisms in Enteroendocrine Carcinomas
Introduction: Enteroendocrine tumors dramatically lack reliable biomarkers to accurately select therapeutic strategy, due to a poor knowledge of molecular mechanisms leading to local invasion and dissemination.
Aim(s): To identify novel proteins involved in the acquisition of the invasive phenotype, defining the malignant behavior of the tumor.
Materials and methods: We used an original orthotopic xenograft model reproducing local invasion and metastatic dissemination. We compared the protein expression pattern at two stages of tumor development: non-invasive and invasive stage, through a proteomic analysis followed by validation in mouse tumors, as well as in human enteroendocrine carcinomas.
Conference: 8th Annual ENETSConcerence (2011)
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