A Role of TETs and 5-Hydroxymethylcytosine in SI-NETs

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Introduction: Small intestinal neuroendocrine tumors (SI-NETs) are rare and slow growing neoplasms. Identification of patients with worse outcome and of novel potential targets for therapy is important goals. The epigenetic mark 5-hydroxymethylcytosine (5-hmC) is severely reduced in various cancers and was recently found by us to discriminate between parathyroid adenoma and carcinoma. A growth regulatory role of TET1 was also found.

Aim(s): To investigate 5-hmC level and TET protein expression in SI-NETs.

Materials and methods: Here we will present results from analyzing the 5-hydroxymethylome in a total of 38 primary SI-NETs and metastases from 19 patients, by immunohistochemistry, DNA immune-dot blot, and colony forming assays.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Barazeghi E, Prabhawa S, Hellman P, Norlén O, Stålberg P,

Keywords: SI-NET, 5-hydroxymethylcytosine, TETs,