Association Between Activin A & NT-pro-BNP in Carcinoid Heart Disease and Intestinal Desmoplasia in Patients with Metastatic Midgut and Pelvic NET


Introduction: Carcinoid heart disease (CHD) involves cardiac valvular fibrosis and volume overload. N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is released by the myocardium in response to increased wall stress in CHD. Activin A is a member of the TGF-ß superfamily involved in fibrogenesis.

Aim(s): To compare Activin A and NT-pro-BNP as biomarkers for detecting CHD and to determine the utility of Activin A as a biomarker in CHD and NET-related desmoplasia.

Materials and methods: Plasma samples from 56 patients with metastatic midgut or pelvic NET were analyzed using ELISA. All patients underwent echocardiography and abdomino-pelvic CT.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Knight D, Khan M, Gobinathan S, Nair D, Toumpanakis C,

Keywords: carcinoid heart disease, desmoplasia, fibrosis, neuroendocrine tumors, activin a, nt-pro-bnp,

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