Atypical lung carcinoid tumor metastatic to endocrine glands and bone marrow

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Introduction: Bronchopulmonary neuroendocrine tumors (BP-NETs) comprise 20% of all lung cancers. Typical low grade carcinoid tumors (TC) represent the majority of BP-carcinoids. Intermediate grade atypical carcinoid tumors (AC) are less often encountered but more aggressive. Although metastatic dissemination to mediastinal lymph nodes, liver, skeleton and central nervous system (CNS) is common, involvement of the endocrine glands has rarely been reported.

Aim(s): We present a case of a 54-year-old male with an atypical lung carcinoid tumor metastatic to endocrine glands and bone marrow.

Materials and methods: The patient presented with severe headache, left temporal hemianopsia, ptosis of the left eyelid, erectile dysfunction, polyouria and polydipsia. MRI of the brain revealed a large pituitary mass of 3.5 cm in diameter that compressed the optic chiasm and infiltrated the left cavernous sinus. Chest x-ray revealed a mass located by the right hilum that was confirmed by CT scan of the thorax. CT scan of the abdomen revealed an enlargement of the right adrenal gland measuring 3 cm.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author:

Authors: Daraki V, Agelaki S, Milaki G, Mamalaki E, Georgoulias V,

Keywords: atypical carcinoid tumor, lung, multiple metastases, pituitary, adrenal, bone,