Comparative Genomic Analysis of High Grade Neuroendocrine Neoplasms across Diverse Organs
Introduction: Grade 3 neuroendocrine neoplasms (G3 NENs), if poorly differentiated, have a median survival of 10-19 months. Little is known regarding biologic differences between G3 NENs from different primary sites, most commonly GI and lung.
Aim(s): Determine via multiomics approach whether G3 NENs are homogeneous or heterogeneous based on primary site.
Materials and methods: We applied multiomics analysis to 46 cases of G3 NEN, both well and poorly differentiated, that included copy number analysis, whole exome, and transcriptomic sequencing.
Conference: 17th Annual ENETSConcerence (2020)
Presenting Author: Sun T
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