Comparative Genomic Analysis of High Grade Neuroendocrine Neoplasms across Diverse Organs

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Introduction: Grade 3 neuroendocrine neoplasms (G3 NENs), if poorly differentiated, have a median survival of 10-19 months. Little is known regarding biologic differences between G3 NENs from different primary sites, most commonly GI and lung.

Aim(s): Determine via multiomics approach whether G3 NENs are homogeneous or heterogeneous based on primary site.

Materials and methods: We applied multiomics analysis to 46 cases of G3 NEN, both well and poorly differentiated, that included copy number analysis, whole exome, and transcriptomic sequencing.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Sun T

Authors: Sun T, Van Hummelen P, Martin B, Xia C, Zhao L,

Keywords: grade 3, high grade, neuroendocrine carcinoma, whole exome sequencing, rna-seq, transcriptomics, copy number analysis, sequencing, genomics, poorly differentiated,