Correlation Between Chromogranin A and RECIST in Neuroendocrine Tumors’ Treatment

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Introduction: High Chromogranin A (CGA) levels have been associated with both tumor burden and the secretory activity of GEPNETs specially carcinoids.

Aim(s): To corralate serum CGA concentrations against Response Evaluation Criteria In Solid Tumors (RECIST) in NETs with carcinoid histology.

Materials and methods: Events were defined as objective response rate (ORR) achieved during pharmacological therapy. ORR was evaluated by RECIST. CGA response was considered a reduction ≥50% from baseline, progression an increase ≥30% and stabilization any other condition. CGA positive and negative predictive values (PPV and NPV) were determined for response, clinical benefit (response + stable disease) and progression. Data were obtained from clinical expedients of patients treated in the Medical Oncology Department from a University Hospital during 2011.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: Fonseca P

Authors: Solís M, Fonseca P, Uriol E, Faez L, Pérez Q,

Keywords: Chromogranin A, response, RECIST, predictive values,