Differential TGF-β Signalling in Typical and Atypical Bronchial Carcinoids


Introduction: Typical and atypical bronchial carcinoids (TBC and ABC) are well-differentiated neuroendocrine neoplasms (NEN). Metastatic BC having low to moderate mitotic count may still be treated with somatostatin analogues and mTOR inhibitors; however, TBC and ABC have been reported to respond very differently to therapy and an effective treatment algorithm is still lacking. TGF-β is known for its ability to activate mTOR pathway and induce epithelial mesenchymal transition, affecting cell pathophysiological capabilities such as proliferation, migration and tissue invasiveness.

Aim(s): Investigate TGF-β downstream protein levels that could explain the differential behaviour found in BC.

Materials and methods: Total proteins were extracted from 4 TBC and 3 ABC fresh tissues. TGF-β downstream signalling protein levels were analysed by Western blot. Protein levels were normalised to GAPDH.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Borges de Souza P

Authors: Borges de Souza P, Tagliatti V, Capobianco S, Ambrosio M, Chinnici S,

Keywords: Neuroendocrine neoplasms, bronchial carcinoids, TGF-β,

To read the full abstract, please log into your ENETS Member account.