Does Small Mean Benign? Not for the WHO 2010 Classification of Gastrointestinal Neuroendocrine Tumors (NETs): A Case Report of a Small Rectal Neuroendocrine Neoplasm (NEN) with Distant Metastatic Spread

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Introduction: The gastrointestinal tract is the most common site of primary NETs, just over a quarter of which are rectal. According to the WHO 2000/2004 non-functioning NETs, ≤2cm with no muscularis propria or vascular invasion are classified as well differentiated (WD) NET with benign behavior. However, several case series report metastatic spread from NETs in this category. In 2010, a new WHO classification was introduced with the premise that all NETs were considered malignant with metastatic potential.

Aim(s):

Materials and methods: We present a case of a small rectal NEN with distant metastatic spread and discuss the importance of using the WHO 2010 classification.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Green A, Cheung V, Toumpanakis C, Caplin M, Luong T,

Keywords: neuroendocrine tumor, WHO,