Efficacy and Tolerance of a Simplified Combination of Streptozotocine and Epi-adriamycine in Metastatic Foregut Neuroendocrine Tumor (NET). A Pilot Study

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Introduction: Since more than 30 years the combination of Adriamycine (A) and Streptozotocine (STZ) is considered as one of the standard chemotherapy regimens (Moertel et al, N Engl J Med 1992, 326 : 519-23) for patients with aggressive grade 2 metastatic pancreatic NET (PNET).

Aim(s): To evaluate tolerance and efficacy of a simplified schedule in patients with progressive metastatic PNET. This simplified regimen used an equivalent dose/intensity of epi-A and STZ as in the Moertel’s regimen : STZ 600 mg/m² in 1 hour perfusion d1 and d2 and Epi-A: 60 mg/m² d1 every 3 weeks.

Materials and methods: Between 2011 and 2015, 10 patients were treated and their data prospectively entered in the hospital data-base. All patients gave their consent before treatment

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Hirsch L, Lepère C, Zaanan A, Landi B, Vaillant J,

Keywords: pancreatic NET chemotherapy,