Emergency Therapy for Liver Metastases from Advanced VIPoma: Surgery or Transarterial Chemoembolization

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Introduction: VIPoma is a rare neuroendocrine tumor (NET) with a high potential to develop hepatic metastases and poor prognosis. The primitive tumor is non-symptomatic and usually localized within the pancreas. Liver metastasis drove the prognosis and induced profuse watery diarrhea or renal failure.

Aim(s): We herein present severe renal failure or diarrhea in 2 patients hospitalized in intensive care justifying emergency treatment of liver metastasis.

Materials and methods: Two patients experienced severe diarrhea due to a hyper secretion of vasoactive intestinal peptide (VIP) from liver metastasis released into the blood circulation.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Coriat R

Authors: Dréanic J, Lepère C, Mostafa E, Gouya H, Rougier P,

Keywords: vipoma, hepatectomy, Trans Arterial Chemo Embolization (TACE), neuroendocrine tumors (NET), vasoactive intestinal peptide (VIP), systemic chemotherapy,