Expression of PTEN and mTOR in Pancreatic Neuroendocrine Tumors and Their Clinical Significance

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Introduction: mTOR is currently under investigation as a potential target for anticancer therapy. Loss of PTEN, the negative regulators of the PI3K-Akt-mTOR pathway, have been associated with cancer.

Aim(s): To clarify the expression patterns of p-mTOR, mTOR and PTEN in normal islets and primary pancreatic neuroendocrine tumors (pNETs) and their significance in predicting clinical behaviors and outcomes.

Materials and methods: The expressions were assessed in 20 normal pancreatic islets and in 90 resectable pNETs.

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author:

Authors: Han X, Ji Y, Zhao J, Xu X, Lou W,

Keywords: pNET, mTOR, PTEN, ICH, clinical behavior, prognosis,