FOXM1 Is Strongly Associated with Cell Proliferation and Is Not Influenced by Metabolic Syndrome in GEP-NETS

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Introduction: Gastro-entero-pancreatic neuroendocrine tumors(GEP-NETs) and metabolic syndrome(MS) are both increasing exponentially. MS has been associated with several non NET cancers.

Aim(s): To evaluate the influence of MS and their individual criteria in GEP-NETs expression of cell proliferation and inflammation molecular markers.

Materials and methods: IHC studies for Ki-67, FOXM1, IGF1R and IL-6 were performed in GEP-NETs paraffin-embedded tissue(n=39) and its expression was quantified by computerized image analysis.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Pereira R

Authors: Pereira R, Pereira S, Morais T, Costa M, Sampaio P,

Keywords: GEP-NETs, metabolic syndrome, FOXM1, IGF1R, IL-6, Ki67 ,