Gastric Neuroendocrine Neoplasms and Long-Term Proton Pump Inhibitors: Need for a Revision of Classifications?

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Introduction: Gastric neuroendocrine neoplasm (gNENs) include three types: type 1 and 2 related to hypergastrinemia due to chronic atrophic gastritis(CAG) or Zollinger-Ellison syndrome (ZES) respectively, and type 3 normogastrinemic and more aggressive. Few cases of gNENs in patients taking proton pump inhibitors (PPI) have been reported

Aim(s): To describe two cases of gNENs in patients on long-term PPI and not classifiable according to current criteria

Materials and methods: From January 2005 to July 2014, 30 gNENs were referred to our Unit. Out of these, 24 (80%), one (3.3%) and three (10%) had type 1, 2 and 3 respectively. Two cases (6.7%) were undetermined according to current classifications

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Cavalcoli f

Authors: Cavalcoli F, Zilli A, Conte D, Ciafardini C, Massironi S,

Keywords: PPI, gNEN, classification, CAG,