Grading NET: Mitosis and Ki-67 conditio sine qua non?

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Introduction: The latest WHO classification for neuroendocrine tumors (NET) defines their grade according to Ki-67 and mitotic index. However, as both parameters are markers for a different part of the cell cycle, their values might not lead to the same grade.

Aim(s): We investigated whether Ki-67 and mitotic index assesment would lead to discordant grading and which of both is most informative to predict survival.

Materials and methods: Tumors of 252 patients with NET were analyzed for mitoses and Ki-67 index. Up till now, survival data are available from 85 patients

Conference: 10th Annual ENETSConcerence (2013)

Presenting Author: van Velthuysen M

Authors: Van Velthuysen M, Korse T, Van der Pol A, Tesselaar M, Taal B,

Keywords: grade, Ki-67, mitosis, NET,