Histological Classification of Pancreatic Neuroendocrine Tumours: Optimising the Ki67 System


Introduction: Pancreatic neuroendocrine tumours are graded using the Ki67 antigen in accordance with the WHO 2010 classification. Despite the system’s widespread use, a wide variety of tumour behaviours have been described leading to various proposed revisions.

Aim(s): To investigate: a) the use of 5% rather than 2% as the boundary between Grades 1 and 2, b) the use of 55% rather than 20% as the boundary between Grades 2 and 3, c) the subdivision of Grade 3 using poorly vs well-differentiated appearances.

Materials and methods: Of 223 patients who visited our institution between 2004 and 2013, Ki67 values were known for 168. Where data was available for the pancreas and liver metastases, the highest value was used. The significance of each system was investigated using Kaplan-Meier survival curves and specific Ki67 values searched for using ROC.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author:

Authors: Mills L, Ramage J, Prachalias A, Srinivasan P, Menon K,

Keywords: G3,

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