Initial Experience of Biological Stability and Image Timing of Ga-68 DOTANOC in Somatostatin Receptor (sstr) Expressing Organ and Tumor

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Introduction: Since Ga68 DOTATATE has a high affinity to only sstr2 but no affinity to sstr3 and sstr5, Ga68 DOTANOC has been suggested to be a better radioligand with higher affinity to sstr3 and sstr5 and high affinity to sstr2, as well.

Aim(s): In this study, we aimed to compare early and late image quality of DOTANOC in sstr positive organ and tumor by using SUVmax and to show in vivo stability of radiopeptide during examination time.

Materials and methods: Sixteen patients (F/M:8/8, mean age 54.72±14.61) with NET were injected with 68Ga-DOTANOC, and whole body PET/CT images were acquired for 30-60-90 min. Images were evaluated visually and SUVmax values obtained in different time points from sstr expressing organs and lesions were compared. Urine samples were obtained from five patients at 30 min and 120 min after radiopeptide administration. Blood samples were also obtained from these patients before radiopeptide application. Radiolabeled metabolites in blood and urine were analyzed by using HPLC.

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Demirci E, Kabasakal L, Ocak M, Aygun A, Ozcan R,

Keywords: Octreotide PET,