Integrative Genomic Characterization Identifies Molecular Subtypes of Lung Carcinoids

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Introduction: Lung carcinoids (LCs) are rare and slow growing primary lung neuroendocrine tumors. The WHO classify LCs into atypical and typical carcinoids. Recent studies have shown that the reproducibility of LCs classification and its prognostic efficacy have high interobserver variability

Aim(s): The aim of this study was to investigate oncogenesis pathways, clinically relevant distinct molecular subtypes of LCs and biomarkers discovery

Materials and methods: We performed targeted exome (MSK-IMPACT) sequencing using a 354-cancer gene panel(n=29), mRNA sequencing(n=30), DNA methylation array(n=18) and Immunohistochemistry(n=20) on macro-dissected lung carcinoids. To validate the molecular subtypes of LCs, we used an independent genomic dataset of LCs that includes exome sequencing(n=70) and gene expression(n=65). In addition, a tissue microarray containing 173 independent cases of LCs was used to study clinical correlates.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Laddha S

Authors: Laddha S, da Silva E, Robzyk K, Untch B, Ke H,

Keywords: MEN1, Lung Carcinoid, Lung Cancer, ASCL1, Novel Molecular Subtypes, Genotype to Phenotype, Integrative Genomic Analysis, Biomarkers, Genomics and Epigenomics,