Long-Term Stable Disease with Everolimus in a Patient with Advanced Pancreatic Neuroendocrine Tumor Enrolled in RADIANT-1

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Introduction: The phase II open-label RADIANT-1 study evaluated the safety and efficacy of Everolimus (E, 10 mg/d) ± octreotide LAR (O) in patients (pts) with advanced pancreatic neuroendocrine tumors (pNET) after chemotherapy failure. Objective tumor response was 9.6% in the E group and 4.4% in the E+O group (all partial), and stable disease (SD) was 68% and 80%.

Aim(s): We report long-term SD in a glucagonoma pt enrolled in RADIANT-1.

Materials and methods: A man aged 46 was diagnosed with glucagonoma in 1990 with tumors in the pancreas (4 cm) and liver (5 cm): p-glucagon >1000 ng/L (ref,

Conference: 9th Annual ENETSConcerence (2012)

Presenting Author:

Authors: Falkerby J, Granberg D, Eriksson B, Skogseid B, Öberg K,

Keywords: neuroendocrine, Everolimus, pancreatic,