Merkel Cell Carcinoma of the Knee Treated with Somatostatin Analogue and Radiotherapy: A Case Report

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Introduction: Merkel cell carcinoma (MCC) is a rare and aggressive primary cutaneous neuroendocrine malignancy. Chemotherapy with cisplatin (CDDP) and etoposide (VP16) is an effective treatment for metastatic MCC.

Aim(s): to describe a case of MCC located on the knee in advanced stage, not eligible for standard therapy with CDDP and VP16 and treated with somatostatin analogues plus radiotherapy (RT).

Materials and methods: a 76 year old man was referred to our center in March 2012 complaining a 8 cm symptomatic (painful and limitation of motion), vegetating and ulcerated lesion of the right knee. Biopsy of the lesion revealed MCC (ki 67 91%, CgA + NSE + CD 117 – TTF1 -); CT scan and Octreoscan showed lesion in the right knee and homolateral inguinal lymph-node metastases. Because of HCV+ cirrosis with thrombocytopenia (93.000/mm3), patient was ineligible to chemotherapy with CDDP and VP16, therefore he received somatostatin analogue plus RT.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author:

Authors: Puliafito I, Falsaperla D, Mare M, Blanco G, Memeo L,

Keywords: merkel cell carcinoma, somatostatin analogues, radiotherapy.,