Pancreatic Neuroendocrine Tumor Presenting in Pregnancy with Severe Hypercalcemia

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Introduction: Malignant hypercalcemia secondary to pancreatic neuroendocrine tumor (pNET) is a rare occurrence with no standard management. We report a challenging case of pNET presenting during pregnancy and complicated by severe hypercalcemia.

Aim(s): We discuss the mechanisms of hypercalcemia and the therapeutic interventions used.

Materials and methods: A 23-year-old woman presented at 26 weeks of gestation with persistent vomiting. MRI showed large pancreatic mass and innumerable liver lesions. Biopsy revealed well-differentiated NET having a Ki-67 of 15%. She commenced sandostatin LAR, however, presented four weeks later with severe hypercalcemia of 20 mg/dl (8.5-10.5 mg/dl). PTH was suppressed but PTHrP elevated.

Conference: 11th Annual ENETSConcerence (2014)

Presenting Author: Assi R

Authors: Assi R, Shamseddine A,

Keywords: pregnancy, pNET, hypercalcemia, embolisation,