Paraneoplastic Antigen Ma2 Autoantibodies as Specific Blood Biomarkers for Detection of Early Recurrence of Small Intestine Neuroendocrine Tumors

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Introduction: Small intestine neuroendocrine tumors (SI-NETs) are rare fatal cancers. Many patients develop metastatis before diagnosis. There is no available curative treatment for patients with metastasis.

Aim(s): Ma2 is a new SI-NET biomarker. The goal is to evaluate whether anti-Ma2 detection in the blood is useful for clinical patient management.

Materials and methods: A novel indirect enzyme-linked immunosorbent assay (ELISA) was set up to detect Ma2 autoantibodies in blood. One-hundred and ninety blood samples from patients with SI-NET, typical and atypical lung carcinoids, different stage of disease, were used. Immunohistochemistry, Western blot, Sequential Immunoprecipitation and Immuno-Dot-blot analyses were used in the study.

Conference: 8th Annual ENETSConcerence (2011)

Presenting Author:

Authors: Cui T, Hurtig M, Li S, Veronesi G, Essaghir A,

Keywords: Ma2, blood biomarker, ELISA, autoantibody, RFS, sequential immunoprecipitation, immuno-dot-blot,