Peripheral Blood Biomarkers of Systemic Inflammation May Be Prognostic in Metastatic Gastroenteropancreatic Neuroendocrine Tumour (GEPNET) Patients Following 177Lu-DOTATATE (LuTate)

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Introduction: LuTate is a treatment for well-differentiated NETs with adequate somatostatin receptor expression. Prognostic biomarkers in this population are lacking. Neutrophil-to-lymphocyte ratio (NLR) is prognostic in the majority of solid tumours but is reported to have less value in indolent well-differentiated NETs.

Aim(s): To investigate the prognostic impact of NLR, lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) in patients (pts) with advanced GEPNET.

Materials and methods: We identified pts with well-differentiated GEPNETs who received LuTate for progressive disease or refractory hormonal syndrome. The relationship between baseline biomarkers, histological grade and progression free survival (PFS)/overall survival (OS) was analysed using multivariate regression models. Progression was defined as new or enlarging lesions on 68Ga-DOTATATE PET/CT.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author:

Authors: Hayes A, Hosking E, Thomas D, Sjoquist K, Chan D,

Keywords: prognostic, biomarker, PRRT, LuTate,