Predictive Factors for Antiproliferative Activity of Octreotide LAR in Advanced Neuroendocrine Tumors

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Introduction: The antiproliferative activity of Octreotide LAR in Neuroendocrine Tumors(NETs) has been demonstrated by small retrospective studies and confirmed by a prospective phase III trial(PROMID).However,there are limited data about the duration and predictors of response.

Aim(s): The aim of our retrospective study was to determine the time to radiological progression(TTRP) of disease and the factors that were associated with better response.

Materials and methods: 254 patients with advanced NETs and positive somatostatin receptor scintigraphy were included.Radiological assessment was based on RECIST criteria.Univariate and multivariate analyses were used to identify predictive factors.Median TTRP and 95% confidence intervals were calculated using Kaplan-Meier analysis.

Conference: 12th Annual ENETSConcerence (2015)

Presenting Author: Toumpanakis C

Authors: Toumpanakis C, Laskaratos F, Maragkoudakis E, Naik K, Oikonomopoulos N,

Keywords: octreotide LAR, NETs,