Primary Hyperparathyroidism in patients with gastric carcinoid Tumors type-1: an unusual coexistence

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Introduction: Although a number of familiar endocrine syndromes are associated with primary hyperparathyroidism (PHP), there is no information regarding its prevalence in other sporadic neuroendocrine diseases.

Aim(s): To investigate the prevalence of PHP in patients with gastric carcinoid type-1 (GC-1) tumors.

Materials and methods: Twenty-six patients with biopsy-proven GC-1 tumors were retrospectively studied. Clinical, biochemical, hormonal, and radiological (including computed tomography (CT) and/or magnetic resonance (MR) imaging of the abdomen, and whole body scintigraphy with 111In-pentetreotide (Octreoscan)) information were recorded. The diagnosis of PHP was based on elevated or high normal serum calcium levels and elevated or inappropriate normal parathyroid hormone (PTH) levels. Further tests for the localization of the hyperfunctioning parathyroid glands included neck ultrasound, 99m-Tc-SESTAMIBI scanning, and cervical or upper mediastenal MR imaging studies. Two age- and gender-matched groups of individuals with (n=49) and without (n=34) thyroid autoimmunity and normal gastric endoscopy were used for comparisons.

Conference: 7th Annual ENETSConcerence (2010)

Presenting Author: Gregory K

Authors: Thomas D, Alexandraki K, Nikolaou A, Sougioultzis S, Kaltsas G,

Keywords: gastric carcinoid tumors type-1, primary hyperparathyroidism,