Prognosis and Incidence in Pancreatic and Gastrointestinal Neuroendocrine Neoplasms with Emphasis on “NET G3”: An Analysis of 198 Cases from Japan

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Introduction: Prognostic impact of well differentiated pancreatic neuroendocrine neoplasms (PanNENs) with a Ki67 >20%, provisionally called NET G3, needs to be validated and compared to poorly differentiated neuroendocrine carcinomas (NECs). Moreover, the frequency of NET G3 among gastrointestinal NENs (GI-NENs) has so far not been studied.

Aim(s): The prognostic impact of NET G3 in PanNENs, as well as in GI-NENs, was investigated.

Materials and methods: 122 resected PanNENs and 76 GI-NENs from Japanese patients were histologically graded according to WHO 2010, and a provisionally defined NET G3 category added. The results were correlated with relevant clinicopathologic data.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Kasajima A

Authors: Kasajima A, Tachibana T, Ishida H, Yazdani S, Konukiewitz B,

Keywords: NET G3, GEP-NEN, GI-NET,